Engineering higher affinity T cell receptors using a T cell display system
โ Scribed by Adam S. Chervin; David H. Aggen; John M. Raseman; David M. Kranz
- Book ID
- 113717609
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 550 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0022-1759
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๐ SIMILAR VOLUMES
Antigens are presented to T cells as short peptides bound to MHC molecules on the surface of body cells. The binding between MHC/peptides and T cell receptors (TCRs) has a low affinity and is highly degenerate. Nevertheless, TCR-MHC/peptide recognition results in T cell activation of high specificit
Peptides derived from almost all proteins, including disease-associated proteins, can be presented on the cell surface as peptide-human leukocyte antigen (pHLA) complexes. T cells specifically recognize pHLA with their clonally rearranged T-cell receptors (TCRs), whose natural affinities are limited