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Directed evolution of human T-cell receptors with picomolar affinities by phage display

✍ Scribed by Li, Yi; Moysey, Ruth; Molloy, Peter E; Vuidepot, Anne-Lise; Mahon, Tara; Baston, Emma; Dunn, Steven; Liddy, Nathaniel; Jacob, Jansen; Jakobsen, Bent K


Book ID
109908349
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
240 KB
Volume
23
Category
Article
ISSN
1087-0156

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Directed evolution of human T-cell recep
✍ Li, Yi; Moysey, Ruth; Molloy, Peter E; Vuidepot, Anne-Lise; Mahon, Tara; Baston, πŸ“‚ Article πŸ“… 2005 πŸ› Nature Publishing Group 🌐 English βš– 240 KB

Peptides derived from almost all proteins, including disease-associated proteins, can be presented on the cell surface as peptide-human leukocyte antigen (pHLA) complexes. T cells specifically recognize pHLA with their clonally rearranged T-cell receptors (TCRs), whose natural affinities are limited