Directed evolution of human T-cell recep
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Li, Yi; Moysey, Ruth; Molloy, Peter E; Vuidepot, Anne-Lise; Mahon, Tara; Baston,
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Article
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2005
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Nature Publishing Group
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English
β 240 KB
Peptides derived from almost all proteins, including disease-associated proteins, can be presented on the cell surface as peptide-human leukocyte antigen (pHLA) complexes. T cells specifically recognize pHLA with their clonally rearranged T-cell receptors (TCRs), whose natural affinities are limited