Stimulation of human Bcells via CD40 is known to induce their homotypic aggregation. We show here that anti-mouse CD40 monoclonal antibodies (mAb) also induce B cells to form large, spherical, extremely stable clusters. This clustering is markedly enhanced by co-stimulation with either interleukin-4
β¦ LIBER β¦
Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor
β Scribed by Kay Wheeler; John D. Pound; John Gordon; Roy Jefferis
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 371 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0014-2980
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## Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes To identify the ligand for the B cell-associated antigen CD40, we constructed a chimeric immunoglobulin molecule where the extracellular porti
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