This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of
✦ LIBER ✦
Differential activation and regulation of mitogen-activated protein kinases through the antigen receptor and CD40 in human B cells
✍ Scribed by Naoki Sakata; Hideki Kawasome; Naohiro Terada; Pär Gerwins; Gary L. Johnson; Erwin W. Gelfand
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 144 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0014-2980
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