Energy metabolism in amyotrophic lateral sclerosis
✍ Scribed by Luc Dupuis; Pierre-François Pradat; Albert C Ludolph; Jean-Philippe Loeffler
- Book ID
- 114409619
- Publisher
- The Lancet
- Year
- 2011
- Tongue
- English
- Weight
- 972 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1474-4465
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📜 SIMILAR VOLUMES
Impairment of mitochondrial function might contribute to oxidative stress associated with neurodegeneration in amyotrophic lateral sclerosis (ALS). Glutamate levels in tissues of ALS patients are sometimes altered. In neurons, mitochondrial metabolism of exogenous glutamine is mainly responsible for
Glutamate levels were determined in the fasting plasma of 22 patients with early-stage primary amyotrophic lateral sclerosis (ALS) and compared to those of healthy and diseased controls. There was a significant increase (by approximately loo%, p < 0.0005) in the plasma glutamate of the ALS patients