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Abnormal glutamate metabolism in amyotrophic lateral sclerosis

โœ Scribed by Dr. Andreas Plaitakis; James T. Caroscio

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
465 KB
Volume
22
Category
Article
ISSN
0364-5134

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โœฆ Synopsis

Glutamate levels were determined in the fasting plasma of 22 patients with early-stage primary amyotrophic lateral sclerosis (ALS) and compared to those of healthy and diseased controls. There was a significant increase (by approximately loo%, p < 0.0005) in the plasma glutamate of the ALS patients as compared with the controls. Oral glutamate loading (60 mg of monosodium glutamate per kilogram of body weight, taken orally after overnight fasting) resulted in significantly greater elevations in the plasma glutamate and aspartate levels in the ALS patients than in the controls. Glutamate, a potentially neuroexcitotoxic compound, is thought to be the transmitter of the corticospinal tracts and certain spinal cord interneurons. A systemic defect in the metabolism of this amino acid may underlie primary ALS.

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