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Energetics of Sequence-Specific Protein−DNA Association: Binding of Integrase Tn916 to Its Target DNA †

✍ Scribed by Milev, Stoyan; Gorfe, Alemayehu A.; Karshikoff, Andrey; Clubb, Robert T.; Bosshard, Hans Rudolf; Jelesarov, Ilian


Book ID
127364427
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
181 KB
Volume
42
Category
Article
ISSN
0006-2960

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## Abstract The N‐terminal domain of the Tn916 integrase protein (INT‐DBD) is responsible for DNA binding in the process of strand cleavage and joining reactions required for transposition of the Tn916 conjugative transposon. Site‐specific association is facilitated by numerous protein–DNA contacts