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Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components

โœ Scribed by Y Koyama; Y Yoshioka; H Hashimoto; T Matsuda; A Baba


Book ID
117489819
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
933 KB
Volume
101
Category
Article
ISSN
0306-4522

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Focal adhesion kinase (FAK or pp125FAK) is a cytosolic protein tyrosine kinase which plays an important role in integrin-mediated signal transduction. Adhesion of cells to the substratum correlates with an increase in tyrosine phosphorylation of FAK as well as an associated protein, paxillin. In thi