Thiophenesulfonamides as endothelin rece
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B. Raju; Chengde Wu; Adam Kois; Erik Verner; Ilya Okun; Fiona Stavros; Ming Fai
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Article
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1996
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Elsevier Science
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English
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The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ET A selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 ktM to ET A and ETB receptors, respectively.