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Endothelin may be pathogenic in systemic sclerosis of the heart

✍ Scribed by Elsadig Kazzam; Anders Waldenström; Thomas Hedner; Jan Hedner; Kenneth Caidahl

Book ID
117355361
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
263 KB
Volume
60
Category
Article
ISSN
0167-5273

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✍ P. P. Sfikakis; C. Papamichael; K. S. Stamatelopoulos; D. Tousoulis; K. G. Fragi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 2 views

## Abstract ## Objective Increased endothelin activity may play a role in the pathogenesis of vascular injury, a primary feature of systemic sclerosis (SSc; scleroderma). Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular