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Endothelin, a novel vasoconstrictor peptide, as potent brochoconstrictor

✍ Scribed by Yoshiyuki Uchida; H. Ninomiya; M. Saotome; A. Nomura; M. Ohtsuka; M. Yanagisawa; K. Goto; T. Masaki; S. Hasegawa


Book ID
115881318
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
119 KB
Volume
154
Category
Article
ISSN
0014-2999

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Endothelin-1 is a potent vasoconstrictor that is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists including PD 159110 (31), an ETA selective antagonist, and PD 159020 (37), a non-selective ETA/ETB antagonist. The discovery,