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Endothelin-1 Production and Its Involvement in Cardiovascular Diseases

✍ Scribed by Mamoru Ohkita; Masanori Takaoka; Yasuo Matsumura

Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract The complex pathogenesis of chronic renal disease (CRD) depends on endothelin (ET) axis (ETs and ET receptors) and nitric oxide (NO) because of their vasoactive effects and their role in general modulation of vascular homeostasis. Various renal cells synthesize ETs and NO that play a si