Endothelin-1 in patients with complicated and uncomplicated myocardial infarction

✍ Scribed by Lechleitner, P. ;Genser, N. ;Mair, J. ;Maier, J. ;Artner-Dworzak, E. ;Dienstl, F. ;Puschendorf, B.

• Publisher: Springer-Verlag
• Year: 1992
• Tongue: English
• Weight: 286 KB
• Volume: 70
• Category: Article
• ISSN: 1432-1440
• DOI: 10.1007/bf00184545

✦ Synopsis

Endothelin-I concentrations were measured in peripheral venous blood samples from 42 patients with acute myocardial infarction. In patients with ischemic or hemodynamic complications (n=11), endothelin-1 concentrations were significantly higher already on admission (P= 0.008) and remained significantly higher until day 6 after admission compared to patients with uncomplicated infarctions (n=31; P=0.035). There were no close correlations between peak concentrations of endothelin-1 and creatine kinase or creatine kinase isoenzyme MB mass in either group. Only in complicated patients did left ventricular ejection fraction correlate closely and inversely with peak endothelin-1 concentrations (r = -0.71 ; P = 0.03). Therefore, plasma endothelin-1 concentrations in patients with acute myocardial infarction patients may reflect states of markedly depressed cardiac performance and recurrent myocardial ischemia.