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Endothelin-1 and insulin induce cellular inactivation of protein kinase FA/glycogen synthase kinase-3α in a common signaling pathway

✍ Scribed by Low-Tone Ho; You-Chung Chou; Jau-Song Yu; Shiaw-Der Yang


Book ID
112718853
Publisher
BioMed Central
Year
1996
Tongue
English
Weight
743 KB
Volume
3
Category
Article
ISSN
1021-7770

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Calphostin C induces tyrosine dephosphor
✍ Shan-Chih Lee; Shiaw-Der Yang 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 950 KB

The signal transduction mechanism of protein kinase FA/GSK-3a by tyrosine phosphorylation in A431 cells was investigated using calphostin C as an inhibitor for protein kinase C (PKC). Kinase F A / C S K -~~ could be tyrosine-dephosphorylated and inactivated to -10% of control in a concentration-depe