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Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage

✍ Scribed by Starke, Robert M; Kim, Grace H; Komotar, Ricardo J; Hickman, Zachary L; Black, Eric M; Rosales, Maritza B; Kellner, Christopher P; Hahn, David K; Otten, Marc L; Edwards, John


Book ID
109870973
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
140 KB
Volume
28
Category
Article
ISSN
0271-678X

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Simvastatin attenuation of cerebral vaso
✍ Takashi Sugawara; Robert Ayer; Vikram Jadhav; Wanqiu Chen; Tamiji Tsubokawa; Joh 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

## Abstract The mechanisms involved in simvastatin‐mediated attenuation of cerebral vasospasm after subarachnoid hemorrhage (SAH) are unclear. We investigated the role of the phosphatidylinositol 3‐kinase/Akt (PI3K/Akt) pathway and endothelial nitric oxide synthase (eNOS) in the cerebral vasculatur