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Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis

✍ Scribed by Nancy Rodig; Timothy Ryan; Jessica A. Allen; Hong Pang; Nir Grabie; Tatyana Chernova; Edward A. Greenfield; Spencer C. Liang; Arlene H. Sharpe; Andrew H. Lichtman; Gordon J. Freeman

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
317 KB
Volume
33
Category
Article
ISSN
0014-2980

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## Abstract Programmed death 1 (PD‐1) and its ligand (PD‐L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of cytotoxic CD8^+^ T lymphocytes, the main effector cells in hepatocellular carcinoma (HCC) patients, are not well de