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No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation

✍ Scribed by Katharina Pfistershammer; Christoph Klauser; Winfried F. Pickl; Johannes Stöckl; Judith Leitner; Gerhard Zlabinger; Otto Majdic; Peter Steinberger


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
449 KB
Volume
36
Category
Article
ISSN
0014-2980

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## Abstract B7‐H3 belongs to the B7 superfamily, a group of molecules that costimulate or down‐modulate T‐cell responses. Although it was shown that B7‐H3 could inhibit T‐cell responses, several studies – most of them performed in murine systems – found B7‐H3 to act in a costimulatory manner. In th