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Endothelial cell responses to chitin and its derivatives

✍ Scribed by Mori, Takashi ;Irie, Yukiko ;Nishimura, Shin-Ichiro ;Tokura, Seiichi ;Matsuura, Mitsunobu ;Okumura, Masahiro ;Kadosawa, Tsuyoshi ;Fujinaga, Toru

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
67 KB
Volume
43
Category
Article
ISSN
0021-9304

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✦ Synopsis

The effects of chitin and its derivatives on the proliferation of human umbilical vein endothelial cells (HUVECs) and on the production of cytokines were examined in vitro. Chitin and its derivatives had no effect on the proliferation of cultured HUVECs. N-Sulfonated 70% deacetylated chitin (S-DAC70) stimulated the production of interleukin (IL)-1b, IL-6, IL-8, and tumor necrosis factor (TNF)-a from HUVECs. Compared to S-DAC70, the other materials tested in the present study showed less effect in the stimulation of IL-8 and TNF-a production and had no effect in the stimulation of IL-1b and IL-6 production. These results indicated that S-DAC70 affects HUVECs function but not proliferation.

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