## Abstract The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPSโassociated proteins, suggesting the UPS dysfunction ma
Endosomal transport of neurotrophins: Roles in signaling and neurodegenerative diseases
โ Scribed by Francisca C. Bronfman; Claudia A. Escudero; Joachim Weis; Alex Kruttgen
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2007
- Tongue
- English
- Weight
- 465 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1932-8451
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## Abstract Aralar, the Ca^2+^โdependent mitochondrial aspartateโglutamate carrier expressed in brain and skeletal muscle, is a member of the malateโaspartate NADH shuttle. Disrupting the gene for aralar, __SLC25a12__, in mice has enabled the discovery of two new roles of this carrier. On the one h