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Endoplasmic reticulum stress in the kidney

✍ Scribed by Masanori Kitamura

Publisher: Springer
Year: 2008
Tongue: English
Weight: 284 KB
Volume: 12
Category: Article
ISSN: 1342-1751
DOI: 10.1007/s10157-008-0060-7

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ