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Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle

✍ Scribed by Koji Ikezoe; Masayuki Nakamori; Hirokazu Furuya; Hajime Arahata; Soshi Kanemoto; Takashi Kimura; Kazunori Imaizumi; Masanori P. Takahashi; Saburo Sakoda; Naoki Fujii; Jun-ichi Kira


Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
479 KB
Volume
114
Category
Article
ISSN
0001-6322

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Therapeutics development in myotonic dys
✍ Erin Pennock Foff; Mani S. Mahadevan πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 238 KB

## Abstract Myotonic dystrophy (DM1), the most common adult muscular dystrophy, is a multisystem, autosomal dominant genetic disorder caused by an expanded CTG repeat that leads to nuclear retention of a mutant RNA and subsequent RNA toxicity. Significant insights into the molecular mechanisms of R