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Endoplasmic reticulum stress and the ER mitochondria calcium cycle in amyotrophic lateral sclerosis

✍ Scribed by Lautenschlaeger, Janin; Prell, Tino; Grosskreutz, Julian

Book ID
120424491
Publisher
Informa plc
Year
2012
Tongue
English
Weight
262 KB
Volume
13
Category
Article
ISSN
1471-180X

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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the misfolding and aggregation of distinct proteins in affected tissues, however, the pathogenic cause of disease remains unknown. Recent evidence indicates that endoplasmic reticulum (ER) stress plays a