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Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

✍ Scribed by Julie D. Atkin; Manal A. Farg; Adam K. Walker; Catriona McLean; Doris Tomas; Malcolm K. Horne


Book ID
113812209
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
680 KB
Volume
30
Category
Article
ISSN
0969-9961

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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the misfolding and aggregation of distinct proteins in affected tissues, however, the pathogenic cause of disease remains unknown. Recent evidence indicates that endoplasmic reticulum (ER) stress plays a