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Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis

✍ Scribed by Kutty Selva Nandakumar; Mattias Collin; Arne Olsén; Falk Nimmerjahn; Anna M. Blom; Jeffrey V. Ravetch; Rikard Holmdahl


Book ID
102167514
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
312 KB
Volume
37
Category
Article
ISSN
0014-2980

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## Abstract ## Objective To investigate the role of interleukin‐17 (IL‐17) in inflammatory arthritis by blockade with an IL‐17 receptor/human IgG1 Fc fusion protein (muIL‐17R:Fc) in adjuvant‐induced arthritis (AIA) in the rat. ## Methods AIA was induced in 39 DA rats with the use of Freund's com