Glycosylation of IgG, immune complexes and IgG subclasses in the MRL-lpr/lpr mouse model of rheumatoid arthritis
β Scribed by Angela Bond; Anne Cooke; Frank C. Hay
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 467 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Sera from 10 patients with juvenile arthritis (JA), 2 seropositive and 8 with hidden rheumatoid factor (RF), were subjected to affinity chromatography on a rabbit antiβhuman IgM column. Material retained by the column was eluted sequentially by 1__M__ NH~3~ and 0.1__M__ glycineβHCl buff
IgG subclass analysis by enzyme-linked immunosorbent assay of the autoantibody to native type I1 collagen, detected in 9 patients with classic or definite rheumatoid arthritis, demonstrated a predominance of IgG3 autoantibody. Gm allotyping revealed no obvious association with a particular phenotype