Endogenous inhibitors of lipoxygenase
β Scribed by Sheikh A. Saeed; Mary Drew; Harry O.J. Collier
- Book ID
- 115875866
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 141 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0014-2999
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π SIMILAR VOLUMES
The syntheses of 5-hydroxamyl and 5-hydroxamylmethyl-6,8,11,14,-eicosatetraenoic acids (3 and 2), which possess potent 5-lipoxygenase inhibitory activity, are described.
## Abstract Health benefits associated with diets rich in anthocyanins are ascribed to multilevel biological activities including antioxidative and antiβinflammatory effects. The present study addresses lipoxygenase inhibition as a mechanism by which anthocyanins may exert health promoting effects.
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15l