Eicosatetraenehydroxamates: inhibitors of 5-lipoxygenase
β Scribed by F.A.J. Kerdesky; J.H. Holms; S.P. Schmidt; R.O. Dyer; G.W. Carter
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 236 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The syntheses of 5-hydroxamyl and 5-hydroxamylmethyl-6,8,11,14,-eicosatetraenoic acids (3 and 2), which possess potent 5-lipoxygenase inhibitory activity, are described.
π SIMILAR VOLUMES
The preparation of hydroxylamine analogs of 2,6-di-tert-butylphenols (DTBP) and the inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) by these compounds is discussed.
Syntheses of 7,7-and 10,10-dimethyleicosa-5(Z1,8(Z),ll(Z1-trienoic acids (zand $1, which possess 5-lipoxygenase inhibitory activity, are described. Arachidonic acid (L) is now well established as a key substance in the biosynthesis of the leukotrienes, a family of compounds that have been implicated