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Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification?

✍ Scribed by H. M. Praag; J. Korf

Book ID: 104758888
Publisher: Springer
Year: 1971
Tongue: English
Weight: 299 KB
Volume: 19
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00402638

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✦ Synopsis

The influence of i.v. administered probenecid on the 5-I-IIAA concentration in the CSF was studied in a group of patients with vital ("endogenous") depression and a non-depressive control group.

The average increase of the 5-ttIAA concentration in the CSF after probcnecid administration was smaller in the depressive group than in the control group. Moreover, the depressive group included patients with a normal as well as patients with a subnormal probenecid effect. This could mean, that the group of vtal depressions encompasses two bioehemically different categories: patients with and patients without demonstrable disturbances in the metabolism of 5-tIT in the brain.

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