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Endogenous C-terminal fragments of beta-amyloid precursor protein from Xenopus laevis skin exudate

✍ Scribed by Christine Clamagirand; Boutaïna El Abida; P. Arsene Der Garabedian; Chantal Hanquez; Lionel Dubost; Arul Marie; Mohamed Rholam; Bertrand Friguet; Paul Cohen

Book ID
116345203
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
972 KB
Volume
146
Category
Article
ISSN
1096-4959

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Amyloid plaques, found in characteristically large numbers in specific brain areas of Alzheimer's disease (AD) and Down's Syndrome (DS) patients, are composed of a 4 1 4 3 amino acid peptide, A4, derived from a transmembrane glycoprotein, amyloid precursor protein (APP). In transformed cells APP has