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Encapsulation of Bovine Serum Albumin in Temperature-Programmed “Shell-in-Shell” Structures

✍ Scribed by Yun-Suk Jo; Do-Kyung Kim; Young-Keun Jeong; Kyung-Ja Kim; Mamoun Muhammed


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
232 KB
Volume
24
Category
Article
ISSN
1022-1336

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✦ Synopsis


Abstract

A novel approach to load a hydrophilic bovine serum albumin into drug carriers was proposed in terms of temperature‐programmed “shell‐in‐shell” structures, which were fabricated with poly(N‐isopropylacrylamide), poly(lactide), poly(ethylene glycol), and Au nanoparticles. Spherically well‐defined “shell‐in‐shell” structures were constructed by a modified‐double‐emulsion method (MDEM). The lower critical solubility temperature of the structures was manipulated to 36.4 °C which was confirmed by UV/Vis spectroscopy and DSC (Differential Scanning Calorimetry).

TEM image of the Au@PLLA‐PEG@PNIPAAm‐PDLA structure.

magnified imageTEM image of the Au@PLLA‐PEG@PNIPAAm‐PDLA structure.


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