## Abstract Spraying and spraying with an electrostatic field (SEF) were employed to prepare alginate microspheres for delivering proteins, especially for intestinal digestive enzymes and cytokines. The encapsulation efficiency (EE) of a model protein [bovine serum albumin (BSA)] at a pH value lowe
Encapsulation of Bovine Serum Albumin in Temperature-Programmed “Shell-in-Shell” Structures
✍ Scribed by Yun-Suk Jo; Do-Kyung Kim; Young-Keun Jeong; Kyung-Ja Kim; Mamoun Muhammed
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 232 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1022-1336
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A novel approach to load a hydrophilic bovine serum albumin into drug carriers was proposed in terms of temperature‐programmed “shell‐in‐shell” structures, which were fabricated with poly(N‐isopropylacrylamide), poly(lactide), poly(ethylene glycol), and Au nanoparticles. Spherically well‐defined “shell‐in‐shell” structures were constructed by a modified‐double‐emulsion method (MDEM). The lower critical solubility temperature of the structures was manipulated to 36.4 °C which was confirmed by UV/Vis spectroscopy and DSC (Differential Scanning Calorimetry).
TEM image of the Au@PLLA‐PEG@PNIPAAm‐PDLA structure.
magnified imageTEM image of the Au@PLLA‐PEG@PNIPAAm‐PDLA structure.
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