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Enantiospecific synthesis of tetrasubstituted δ-lactones

✍ Scribed by Annabel L. Wilkinson (née Cutter); Ulf Hanefeld; Barrie Wilkinson; Peter F. Leadlay; James Staunton

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
263 KB
Volume
39
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

For investigations concerning the selectivity of polyketide synthases (PKSs) which have been rationally engineered through genetic techniques the synthesis of substituted Slactones is of great importance. An enantiospecific route towards eight of the possible sixteen stereoisomers was developed which is also readily adaptable for the introduction of alkyl modifications and isotopic labels.

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