ChemInform Abstract: Synthesis of Tetrasubstituted δ-Lactones.
✍ Scribed by C. CLISSOLD; C. L. KELLY; K. W. M. LAWRIE; C. L. WILLIS
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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## Pyran derivatives R 0340 Diastereoselective Synthesis of Functionalized δ-Lactones. -The diastereocontrol of the title reactions depends on the substituent of the glutarate. -(SAMARAT, A.;
## Abstract A novel and general synthesis of δ‐lactones from glutaraldehyde is described. The dialdehyde is first reacted with an alkyl or substituted alkyl __Grignard__ reagent to afford a δ‐hydroxyaldehyde in good yield. These aldehydes exist preferentially in the cyclic hemiacetal form (δ‐lactol
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