Enantiospecific Synthesis of Pyridinylmethyl Pyrrolidinemethanols and Catalytic Asymmetric Borane Reduction of Prochiral Ketones.
β Scribed by Yong-Xin Zhang; Da-Ming Du; Xiao Chen; Shao-Feng Lue; Wen-Ting Hua
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 106 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Easily available D-(+)-camphor-derived chiral mercapt\*alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2-72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved' when mercaptc-alcoh
## Abstract A series of novel __N__βsquaramidoacid ligands were prepared conveniently. Without converting to corresponding amino alcohols, these ligands could be used in asymmetric borane reduction of prochiral aromatic ketones to give secondary alcohols in good to excellent enantiomeric excesses.
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