Enantiospecific synthesis of (+)-hernandulcin
โ Scribed by Francesco G. Gatti
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 150 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
pulegol in seven steps and in 25% overall yield.
๐ SIMILAR VOLUMES
+)-Hernandulcin 1, an extremely sweet bisabolane-type sesquiterpene, and (+)-epihernandulcin 2 were synthesized in six steps from (-)-isopulegol with 15 and 11% overall yields, respectively.
A total synthesis of (+)-herbertene from (+)-camphoric acid is described using a Diels-Alder reaction as the key step.
The alkaloid (+)-ribasine was synthesized by stereocontrolled addition of substituted a-lithium-o-toluate 6d to enantiomerically pure (R)-N-(9-phenylfluoren-9-yl)-2-amino-5,6-(methylenedioxy)indan-l-one [(+)-5]. Aminoindanone (+)-5 was prepared from amino acid (-)-15 obtained by diastereoselective a