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Enantiospecific synthesis of (+)-hernandulcin

โœ Scribed by Francesco G. Gatti


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
150 KB
Volume
49
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


pulegol in seven steps and in 25% overall yield.


๐Ÿ“œ SIMILAR VOLUMES


Synthesis of (+)-hernandulcin and (+)-ep
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+)-Hernandulcin 1, an extremely sweet bisabolane-type sesquiterpene, and (+)-epihernandulcin 2 were synthesized in six steps from (-)-isopulegol with 15 and 11% overall yields, respectively.

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The alkaloid (+)-ribasine was synthesized by stereocontrolled addition of substituted a-lithium-o-toluate 6d to enantiomerically pure (R)-N-(9-phenylfluoren-9-yl)-2-amino-5,6-(methylenedioxy)indan-l-one [(+)-5]. Aminoindanone (+)-5 was prepared from amino acid (-)-15 obtained by diastereoselective a