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Enantiospecific synthesis of (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid by a modified Corey-Link reaction

✍ Scribed by Carmen Domínguez; Jesús Ezquerra; S. Richard Baker; Stéphane Borrelly; Lourdes Prieto; Modesta Espada; Carmen Pedregal


Book ID
108387185
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
239 KB
Volume
39
Category
Article
ISSN
0040-4039

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✍ A. Srikrishna; T. Jagadeeswar Reddy 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 525 KB

Synthesis of the chiral bicyclic ketone mentioned in the title starting from Rcarvone, and its elaboration to 7-epibakkenolide-A is described. Conjugate addition of dimethyl copperlithium to R-carvone followed by alkylation of the intermediate enolate generated the allylated compound 6, which was tr