Enantiospecific syntheses of intermediates in the total synthesis of pseudomonic acids
β Scribed by G.W.J. Fleet; M.J. Gough
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 218 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract An enantioselective synthesis of key intermediates for the synthesis of the antiβmicrobially active pseudomonic acids **A** (**1**), **B** (**2**) and **C** (**3**) is described. DβRibose (**4**) was used as starting material.
The total synthesis of the enantiomer 3En of macroline 3 was completed (from L-tryptophan methyl ester 6) in an overall yield of 12.3% (11 isolated intermediates). The corresponding macroline equivalent 18 was prepared in 14.3% yield. This work provides, for the first time, an opportunity to synthes
The synthesis of the cis-fused y-lactone 2,7-dioxabicycle-&3,4 non-4-en-g-one (3) by two routes is reported. Its stereoselective conversion to a key intermediate for pseudomonic acid synthesis is described.