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Enantioseparation of kavain on Chiralpak IA under normal-phase, polar organic and reversed-phase conditions

✍ Scribed by Roberto Cirilli; Rosella Ferretti; Bruno Gallinella; Anna Rita Bilia; Franco Francesco Vincieri; Francesco La Torre

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
780 KB
Volume
31
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

First baseline HPLC enantioseparation of kavain is described. Complete enantiodiscrimination was achieved on the immobilised‐type Chiralpak IA chiral stationary phase (CSP) using pure methanol and simple methanol‐water and ethanol‐water mixtures as eluents. A water‐dependent enantioselectivity was clearly demonstrated. Performance of the Chiralpak IA CSP in polar organic and RP conditions was compared with that of five coated polysaccharide‐derived CSPs used in normal‐phase mode.

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