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Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers

✍ Scribed by Helena Engman; Christer Tannergren; Per Artursson; Hans Lennernäs

Book ID
114302172
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
253 KB
Volume
19
Category
Article
ISSN
0928-0987

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The objective of this study was to investigate the mechanisms by which berberine is transported in the secretory and absorptive directions across Caco-2 cell monolayers. The basolateral-to-apical (B-A) flux was 30-fold greater than the apical-to-basolateral flux and temperature dependent (i.e., dras