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Enantioselective Synthesis on the Solid Phase

✍ Scribed by Torben Lessmann; Herbert Waldmann


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES


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## Abstract Aliphatic aldehydes were synthesized on a solid support and subjected to an enantioselectively catalyzed oxa‐Diels–Alder reaction with Danishefsky’s diene. Employing 5 mol % of a Cr(III)‐salen catalyst enantiomeric ratios up to>99 % and yields up to 40 % over five steps were achieved. F

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Planar supports represent a unique opportunity in designing novel approaches to solid-phase synthesis of peptides and small organic molecules. Published work includes assembly on cellulose paper sheets, cotton strips, or membranes, as well as ultrahigh-density synthesis on glass supports. Planar car

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