Solid-phase synthesis on planar supports

✍ Scribed by Michal Lebl

• Publisher: Wiley (John Wiley & Sons)
• Year: 1998
• Tongue: English
• Weight: 96 KB
• Volume: 47
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/(sici)1097-0282(1998)47:5<397::aid-bip6>3.0.co;2-u

✦ Synopsis

Planar supports represent a unique opportunity in designing novel approaches to solid-phase synthesis of peptides and small organic molecules. Published work includes assembly on cellulose paper sheets, cotton strips, or membranes, as well as ultrahigh-density synthesis on glass supports. Planar carriers allow for the synthesis to be performed without any reaction vessels (inclusion volume chemistry), construction of libraries with only one representation of each structure, or for continuous synthesis (replacing sequence in time by sequence in space).