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Enantioselective synthesis of δ-ketobutanolides from (l)-glutamic acid via organomanganese reagents

✍ Scribed by Gérard Cahiez; Eric Métais

Book ID
104361125
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
235 KB
Volume
8
Category
Article
ISSN
0957-4166

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✦ Synopsis

Various optically active tS-ketobutanolides were easily prepared in good yields, with an excellent enantiomeric purity, by acylation of organomanganese reagents with the butyrolactone acid chloride 3 prepared from natural (L)-glutamic acid. The reaction takes place in THF under mild conditions (-10°C, 3h or 3% CuCI, -30°C, 20 min.

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