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Enantioselective synthesis of α-carbon deuterium-labelled l-α-amino acids

✍ Scribed by Barry Lygo; Luke D. Humphreys

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
138 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Ph 2 C=N CO 2 t-Bu H H Ph 2 C=N CO 2 t-Bu CH 2 Ph D Ph 2 C=N CO 2 t-Bu D D >98% conversion 40% KOD/D 2 O PhMe, RT, 3h no PTC catalyst + 10mol% nBu 4 NBr add PhCH 2 Br RT, 18h (4) ±(5a) <5% conversion >98% conversion

📜 SIMILAR VOLUMES

Enantioselective synthesis of isotopical
Enantioselective synthesis of isotopically labelled L-α-amino acids preparation of 13C-, 18O-and 2H-labelled L-serines and L-threonines
✍ W. F. J. Karstens; H. J. F. F. Berger; E. R. Van Haren; J. Lugtenburg; J. Raap 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 815 KB

## Abstract [3‐^18^O]‐L‐serine, [3‐^13^C]‐L‐serine, [3‐^18^O]‐L‐threonine, [3,4‐^13^C~2~]‐L‐threonine and [3‐^2^H]‐L‐threonine are prepared from simple commercially available, isotopically enriched starting materials like H~2~^18^O, [^13^C]‐paraformaldehyde, [^13^C~2~]‐acetaldehyde and [1‐^2^H]‐ace