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Enantioselective synthesis of the nagilactone ring system via vinylsilane-mediated polyene cyclization

โœ Scribed by Steven D. Burke; Sharon M.S. Strickland; Helen M. Organ; Louis A. Silks III

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
238 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The functionalized tricyclic nagilactone precursor 19 was synthesized by a route featuring a vinylsilane terminated/1,3-dioxane acetal initiated bicyclization. Relative and absolute stereochemical control were achieved via the optically active pentenolide template 14.

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