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Enantioselective Synthesis of Tertiary α-Hydroxyketones from Unfunctionalized Ketones: Palladium-Catalyzed Asymmetric Allylic Alkylation of Enolates

✍ Scribed by Prof.Prof. Barry M. Trost; Dr. Raffael Koller; Dr. Benjamin Schäffner

Book ID: 112000435
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 490 KB
Volume: 124
Category: Article
ISSN: 0044-8249
DOI: 10.1002/ange.201203663

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Enantioselective Synthesis of Tertiary α

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Palladium-Catalyzed Asymmetric Allylic A

Palladium-Catalyzed Asymmetric Allylic Alkylation of Ketone Enolates

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## Abstract Palladium‐catalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e

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## Abstract Lithium and magnesium enolates of cyclohexanone undergo palladium‐catalyzed allylic alkylations under mild conditions. Diastereoselectivity and enantioselectivity are observed when the diphenyl‐ and dimethyl‐substituted allylic substrates **1a** and **1b** are reacted with cyclohexanone