Enantioselective synthesis of S-o-carboranylalanine via methylated bislactim ethers of 2,5-diketopiperazines
✍ Scribed by Wilhelm Karnbrock; Hans-Jürgen Musiol; Luis Moroder
- Book ID
- 103404843
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 577 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
## Abstract In contrast to porcine pancreatic lipase (PPL), the serine proteases aP 41 and thermitase are suited as catalysts for the enantioselective ester hydrolysis of methyl (π)‐2,3‐__O__‐isopropyl‐ideneglycerate (__rac__‐1). These enzymes allow the preparation of methyl (__S__)‐(−)‐2,3‐__O__‐i
The titanium derivative 4a of the bislactim ether l a from cyclo-(L-Val-Gly) reacts with + m a t u r a t e d aldehydes 5 exclusively by 1.2-addition in a highly diastereowlective mode to give virtually only the (2R,l'S) diastereomers of type 6. Upon hydrolysis these furnish the methyl (2R,3S)-thrm-2