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Enantio- and Diastereoselective Synthesis of Methyl (2R)-2-Amino-5-oxocarboxylates from Enones and Bislactim-Ether Cuprates

✍ Scribed by Prof. Dr. Ulrich Schöllkopf; Dr. Dagmar Pettig; Edda Schulze; Michael Klinge; Dr. Ernst Egert; Bernd Benecke; Mathias Noltemeyer


Book ID
101554429
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
246 KB
Volume
27
Category
Article
ISSN
0044-8249

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📜 SIMILAR VOLUMES


Asymmetric Syntheses via Heterocyclic In
✍ Schöllkopf, Ulrich ;Bardenhagen, Jürgen 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 534 KB

The titanium derivative 4a of the bislactim ether l a from cyclo-(L-Val-Gly) reacts with + m a t u r a t e d aldehydes 5 exclusively by 1.2-addition in a highly diastereowlective mode to give virtually only the (2R,l'S) diastereomers of type 6. Upon hydrolysis these furnish the methyl (2R,3S)-thrm-2