Enantioselective synthesis of ring-C aromatic steroids by asymmetric Michael-type alkylation of chiral imines.

✍ Scribed by Tony Volpe; Gilbert Revial; Michel Pfau; Jean d'Angelo

• Book ID: 104227604
• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 219 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96126-4

✦ Synopsis

Optically active phenanthrones 7 and 12 were prepared, using the asymmetric process involving Michael-type alkylation of chiral imines. Compound 12 was then transformed into the ring-C aromatic steroid 16. We have recently published a very efficient method for the enantioselective construction of compounds bearing quaternary carbon centers