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Enantioselective synthesis of optically pure s-isoserine

✍ Scribed by A. Solladie-Cavallo; N. Khiar

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
201 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

KF-promoted addition of nitromethane on (-)-8-phenylmenthyl glyoxylate monohydrate affords, after one purification, optically pure (-1s isoserine in about 50% yield. Isoserine was found to inhibit several enzymes of serine metabolism in mammals and to interfer with panthotenic acid synthesis from D-alanine in yeast'. More recently, it

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