KF-promoted addition of nitromethane on (-)-8-phenylmenthyl glyoxylate monohydrate affords, after one purification, optically pure (-1s isoserine in about 50% yield. Isoserine was found to inhibit several enzymes of serine metabolism in mammals and to interfer with panthotenic acid synthesis from D-
✦ LIBER ✦
Enantioselective synthesis of optically pure natural S(+) or unnatural R(-) DABA
✍ Scribed by A. Solladié-Cavallo; M.C. Simon
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 274 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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