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Enantioselective synthesis of (−)-indolizidine 239AB [(3R,5S,8aR)-3-butyl-5-(3-hydroxypropyl)-octahydroindolizine]

✍ Scribed by Giang Vo Thanh; Jean-Pierre Célérier; Gérard Lhommet

Book ID
103977580
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
144 KB
Volume
7
Category
Article
ISSN
0957-4166

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✦ Synopsis

A highly enantioselective synthesis of the indolizidine alkaloid 239AB is described via the diastereoselective reduction of a chiral cyclic 13-enamino ester prepared from (S)-pyroglutamic acid.

📜 SIMILAR VOLUMES

ChemInform Abstract: Enantioselective Sy
ChemInform Abstract: Enantioselective Synthesis of (-)-Indolizidine 239AB ((3R,5S,8aR)-3- Butyl-5-(3-hydroxypropyl)-octahydroindolizine).
✍ VO THANH GIANG VO THANH GIANG; J.-P. CELERIER; G. LHOMMET 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Enantioselective Synthesis of (-)-Indolizidine 239AB ((3R,5S,8aR)-3-Butyl-5-(3-hydroxypropyl)-octahydroindolizine). -A general synthesis for the title compound (XI) is presented as part of studies on the reactivity of chiral cyclic β-enamino esters, e. g. (II). (XI) belongs to a class of alkaloids